Posted 14 July 2009 - 08:14 AM
Did you try running sfc /scannow
If you've been doing things to make your registry more efficient and you've run Combofix, you may have caused some damage. The above scan, which can be run from either Start / Run. Copy/paste in the above bold type and click on ok. Or it can be run from the cmd prompt. Start / Run type in cmd and click on ok. In the window that opens up, copy the above bold line and paste it in at the end of the line and click on enter.
If you run the above scan, you may be asked to insert your Windows cd.
The other thing you might want to do is to go to the Am I Infected forum and see if they can check for rootkits.
Also, how is your memory? Is the ram functioning correctly?
Did the slowness occur gradually or after you installed something? Any thoughts on that?