I have the same and although I do the occasional scan with Superantispyware and Malwarebytes Antimalware, they have not found anything so far.
As long as you do not allow something bad to run by giving permission via a Defense+ query (which now has Threatcast to guide you), you would not even test the capability of the Antivirus. Although the av is still developing it is now catching up fast with the best in the business.
There are some interesting tests being posted on the Comodo forum here:http://forums.comodo.com/feedbackcommentsa...t-t33392.0.html
The latest CIS has very few pop-ups to answer using it's default configuration, however I would suggest changing Defense+ to Safe Mode so as not to need to deal with pending files. That does not produce many more pop-ups.