Well...I think I would just use regedit to go to that particular registry line...and see what items might be detailed there...before making a decision.
If no items are there...it's up to you.
The problem with RUN and RUN ONCE entries that I have...is that any application is liable to insert one into your system during program install. So I keep an eye on such, using Autoruns.
Some topics you may want to look at: http://www.google.com/search?hl=en&q=R...mp;aq=f&oq=