Epson Does not have vista drivers for that scanner I did however find a solution on the vista forums. Goto the epson website and download the driver for Windows XP
Extract the contents of the file by running the file (double clicking, or single click depending on your preferences)
Follow the instructions in the extraction wizard and take note of the directory that the files will be extracted to. (probably C:\epson)
Navigate to the directory after the wizard completes, right click on the "Setup.exe" file and select the properties menu item
Now select the "Compatibility" tab and check the box next to the description "Run this program in compatibility mode for:" Select in the drop down "Windows XP (Service Pack
Press OK, or Apply then OK.
Run the Setup.exe file and install the driver as normal. Windows Vista will pop up a message about compatibility.. just select the Install anyway option and everything should work fine.
Hope this helps