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A reformat should wipe all data, but if you restore any files, they might be infected. It's usually a good idea to scan all files you will restore for viruses and trojans. Note that the slowdown can also occur if there are a number of background processes running.
DJBPace07 - but by "restore any files" you mean actually using the System Restore? That was not my intention. I just was thinking format the hard drive and then re-install from scratch all the old software. Does it make sense for me to do this?
By restore old files, I meant things like your MP3 music collection, your downloaded movies and programs, documents, etc. Formatting is the nuclear option in virus control. You will wipe out the virus off a hard drive, assuming you don't have multiple drives that it can move to, but you will also get rid of all your personal data. What virus scanner do you use?
DJBPace07, they had an old version of Norton running but I've since uninstalled it and installed "Free" AVG. I've run a few scans along with Adaware and it found some stuff and helped clean up a little, but still having one functionality problem -- they are using a cable modem to connect and all the sudden it is taking 15-20 minutes to upload a photo to KodakGallery.com and Facebook, etc.
So I assumed(probably my mistake) that there is still a virus or malware present and figured it was easiest(ie. fastest) to just format and wipe out the whole hard drive and just reinstall all the software for them again.