I'm not sure what you are asking.
If you are asking if an infection spreads from one hard drive to another...on the same system...the answer is yes.
Malware targets a system...it doesn't matter what components are on a system. 100 hard drives in a single system, 100 systems on a single network...malware can spread to each/every one.
Malware doesn't play by the rules of normal file transfer...where I would have to copy or move File A to Drive D, if I wanted it there. Malware has it's own unique method of spreading.
This is almost 10 years old...but, IMO, you may gain by reading it: http://www.faqs.org/faqs/computer-virus/new-users/