1st thing I'd try...boot with the drive attached but not on/powered. Turn the drive on after Windows has been on for 5 minutes.
Onboard USB is USB provided as part of the motherboard. If you did not install a PCI card specifically to have USB capability...you have onboard USB
To Uninstall USB Controller: Start/Run...type devmgmt.msc, hit Enter. Click on Universal Serial Bus Controllers. Double-click, go to Driver tab, push Uninstall button...for each device listed as a controller or hub.
To reinstall: Use Drivers CD that came with system or motherboard.
FWIW: You probably should read some of the user comments at http://www.amazon.com/LaCie-Extreme-Extern...U/dp/B000AY8DF0