No single product is 100% foolproof
and can detect and remove all threats at any given time. The security community is in a constant state of change as new infections appear. Each vendor has its own definition of what constitutes malware and scanning your computer using different criteria will yield different results. The fact that each program has its own definition files means that some malware may be picked up by one that could be missed by another. Thus, a multi-layered defense using several anti-spyware products (including an effective firewall) to supplement your anti-virus combined
with common sense and safe surfing habits provides the most complete protection.
However, you can overkill your system with resource heavy security programs that will drain your resources and slow down performance. Sometimes you just have to experiment to get the right combo for your particular system as there is no universal solution that works for everyone.
SpywareBlaster does not
run in the background. Instead it only requires installation and then enabling of all protection. After that you only have to check periodically for database updates using the built-in "Check for Updates" feature and then enable all protection again.
SpywareGuard is a limited real-time protection tool that monitors certain events and then acts to notify you that these events are taking place rather than prevent specific threats. SpywareGuard will notify you of any event attempt to change the browser home page - it makes no judgment on whether the change is good or bad but leaves the decision up to you to allow or deny it.
The free version of SAS does not run in real-time mode...a purchased upgrade to the "Professional" version is required before this option can be activated. See SUPERAntiSpyware Free vs Pro Comparison Features
. If your using the free version, use it as an on-demand scanner...no need to run at startup.
If you are going to use MBAM, there is probably no need to keep Ad-Aware or Spybot, especially if you are going to use the paid version where offers some real-time protection. If you disable Teatimer that would eliminate its start up and you could continue to use Spybot as an on demand scanner like SAS or MBAB if you are not going to use the paid version. Ad-Aware is not as effective as it use to be so you probably wouldn't find much after running the other scans.