For a set-and-forget backup solution, I would recommend Carbonite Online Backup (http://www.carbonite.com/
). This works by backing up you data to Carbonite's data enter over your broadband internet connection. Your data is encrypted before it is backed up, so no-one but you can read it.
The advantage of online backup is that your backup is stored in a physically remote location from your original data. That way, you can get your data back even after some distaster such as fire or flood. Also, once the software is running it is constantly updating your backup, so you don't even have to remember to make routin backups.
The disadvantage is that the initial backup will take some time to complete (1 - 2 weeks, depending on the speed of your connection and the amount of data you have). This means it is not really feasible if you need to back up more than, say, 60GB of data.
You pay a yearly subsription for the service (about $50) for unlimited backup.
I have been using this service for a gew months now, and am very happy with it - no more backup worries for me!