Posted 16 April 2008 - 11:40 AM
Cleaning up registry entries really will not do much good, and the potential for harm far outweighs what little benefit in operating speed you might receive. I do, however, routinely scan my hard drive for folders that remain after I use "add/delete programs" and erase those, as well as other dregs; while this doesn't directly speed up your computer, it does improve the scanning speed of AV and AS applications, and more directly once you defrag a relatively "clean" hard drive it effects your OS.
My own experience with XP after two years of very hard use, is that doing routine maintenance will avoid any sort of re-installation, and every time I have "cleaned out" my registry (I have experimented twice with cleaners), I have lived to regret it.
Whereof one cannot speak, thereof one should be silent.