Run an online scan like Eset/NOD32
Then run a scan with free home version of SUPERAntiSpyware
From safe mode
Restart your computer.
When the machine first starts again it will generally list some equipment that is installed in your machine, amount of memory, hard drives installed etc. At this point you should gently tap the F8 key repeatedly until you are presented with a Windows XP Advanced Options menu.
Select the option for Safe Mode using the arrow keys.
Then press enter on your keyboard to boot into Safe Mode.
Do whatever tasks you require and when you are done reboot to boot back into normal mode.
safe mode Windows Vista
Windows Vista is similar to Windows XP for starting in Safe Mode.
Turn the computer on or Restart the computer
Start tapping the F8 key. The Windows Advanced Boot Options Menu appears. If you begin tapping the F8 key too soon, some computers display a "keyboard error" message. To resolve this, restart the computer and try again.
Ensure that the Safe mode option is selected (the top option)
Press Enter. The computer then begins to start in Safe mode.
When you are finished with troubleshooting, close all programs and restart the computer as you normally would
Please let us know how it is running after scans and a Reboot.