I'm sorry to tell you this, but it looks like you already know it. Your system is massively infected.
Since you use this computer in your work, I don't think you should try to clean it. When a system has been infested as badly as this one, there is no way to be sure that it is "cured." Even if you remove all visible traces of infection there may be other leftovers that you cannot find.
The best solution would be to back up your data, then reformat your C:\ and reinstall Windows, either from your Windows install disk or your computer maker's system recovery disk.
If you can burn CDs on the machine you can backup the data that way. Other alternatives would be a USB flash drive or hard drive.
If Windows is so messed up that you can't use it for file copying or CD burning, then you have to try other methods. If you have access to another computer you can download and burn the Knoppix live Linux CD, then boot your laptop from it. Here is a link
to an online tutorial explaining the basics.
Once the Linux CD is running you can mount the hard drive and copy files off it to a flash drive or burn them to CD -- or upload them to an online file storage service, as one fellow mentions in the combox. The Knoppix CD has a lot of network drivers and in most situations will give you access to the Internet.
The last alternative is to remove the hard drive from the laptop and install it as a "slave drive" in another PC. That is how a professional repair shop would do it. They have adapters that allow you to connect a laptop drive to the IDE cable in a desktop machine. Then they just copy over the data files to the host machine's hard drive. Then they reformat the infected drive and reinstall Windows, Finally, they scan the data files for malware before copying them back.
Hope this gives you some ideas about how to recover your data.