You could eliminate cleaning your mouse now and forever in the future if you were to get an optical mouse. They never require cleaning. Of course, you would need to unplug your old mouse and plug in the new one... but only once. I prefer Microsoft and Logitech models - you don't need to spend over $20 US or so for a good one.
Here's a typical one though I'm a bit partial to Logitech mice: http://cgi.ebay.com/Microsoft-Optical-USB-...1QQcmdZViewItem
Notice that this model is both a PS/2 *and* a USB mouse. This is the best way to go since it will work on any computer. It has a little adapter on the end of the cable that converts the connector from a USB plug to a PS/2 type. (USB is rectangular, PS/2 is round) How you want to use it is up to your computer. Most towers have PS/2 jacks for the mouse and keyboard, though the newest Dells are cheaped out and have only USB jacks.
Here's a PS/2 -only Logitech mouse: http://cgi.ebay.com/Logitech-M-SBF90-BLACK...1QQcmdZViewItem
Oh, by the way, unplugging and re-plugging your mouse and keyboard even while your computer is running is perfectly safe - for you and the computer. If you need to pull your computer out from a cubby then shut it down first. You don't want to be bouncing around the hard drive while it's running.