Don't be too paranoid...
Example: I use SUPERAntispyware & MalwareBytes Anti-Malware on-demand, I scan fortnightly or monthly. I then have COMODO Firewall Pro 3 & No Anti-Virus (Because I believe there is only a limited ways infection), I don't do P2P or download any unknown/untrusted site. I also use Firefox 3. That's it for me.
However, You will still need an AV in most circumstances, especially when you do have E-mail, you do use P2P (Limewire, Utorrent, etc) and download/install/browse of risky web sites. The ultimate protection IMO is common sense and layered security:
Prevention (Eg: Comodo Firewall Pro 3 Defense+/Firewall which does not rely on signatures, uses behavior heuristics and other methods) Defense+ actually protections over 60% unknown malware! Something traditional AV's can't do)
Detection (You're Anti-Virus)
Cure (Back up detection technologies like SAS & MBAM), Maybe Recovery software, etc.
People will have different opinions, this is mine. So "relying on the best Anti-Virus & Anti-Malware product", and ONLY those things isn't good- Because you are just relying on detection, You also need prevention & cure! the 3 steps.
Prevention should be your first line of Defense! You're DETECTION Antivirus (Avast!, Avira, NOD32) & PREVENTION (Comodo Firewall Pro 3 with Defense+) Will work great together. Because your AV uses signatures & CFP 3 doesn't!
This post has been edited by 3xist: 02 August 2008 - 09:19 PM