Personally, I've always liked the KDE desktop over Gnome, so I have been using Kubuntu for a while - which is Ubuntu with a fancier desktop. In the past, I've used a lot of distros, suSe, Red Hat, Mandrake, and I've tried lots of things.
Recently, I got a netbook. I decided to go Kubuntu on that and am not as happy with it as I was on the desktop because it's going to take some tweaking. I have an odd-sized screen and it doesn't quite fit, the touchpad works but feels a bit fast, and so on. But it all does work. I had a bit of a problem hooking to my encrypted wifi until I realized that it wanted me to put in the hex key in a second window as well as the first, and it's connected fine ever since.
Anyway, it works fine on the desktop. I find Ubuntu to be too simple on the surface. It's powerful underneath but is difficult to get used to. Kubuntu is more Windows-like with things in the usual places.