The only real way to build 'wicked' websites is to actually learn html, css, and javascript. Dreamweaver can accomplish this, but not if you don't know what it is you are trying to do. Doing an e-commerce site is beyond just simple html. E-commerce websites require server-side technology to write to databases, process orders, and generate dynamic web pages based on desired content. That will require PHP,C++, Java, Perl, or some other language. That is hard core programming, and not something you are going to throw together in a weekend (or 6 months worth of weekends for that matter). You might be able to find some open source software that will accomplish what you want, but you will then require a server that is capable of running the application.
Something like this:
http://www.phpshop.org/Creating an e-commerce website from scratch requires knowledge of databases, security, data structures, etc. People make a good living creating application like this, and it requires a bit of training and/or schooling. You may want to consider finding an open source package that will do it for you. Find one that has good support so that you have somewhere to turn to when you need help with installation or configuration.