When I open a picture in MS Paint, it is very large.

The HELP section says to go to VIEW, then ZOOM, the choose "normal size."

However, Normal Size is "greyed out."

What do I do?

What are you trying to do? Do you know what resolution your monitor is set to?

Hi stevemalee.
Paint opens the picture in it's normal size by default. The only time that option becomes available is if you zoom in or out. To see what I mean, open an image and and choose large or custom. The normal size will now be an option. You cannot resize an image itself with paint, you can only change the "viewing" size. It is a pixel based program rather then an object based one. If you want to resize the actual image, use something else like xnview, irfanview or some other image editing program that may already be installed on your system.