a pc in work for som reason all of a sudden the screen saver icons and mouse control are all upside down and back to front!!!

No one touched it!!1 what the heck is this!??

Have you installed any hardware or software recently? Have you updated or changed any drivers?

When exactly did this anomaly begin?

If you know when it began the first thing might be to use Windows System Restore to revert your system state to a date predating the problem. (If you are using Win XP or Win ME).

Try pressing Ctrl + Alt + up arrow.

Thanks Enthusiast.

Herks solution was what fixed it! Strange.

Some video cards have the ability to flip the screen. (Nvidia!) If the above solution hadn't worked, the next thing would have been to try going to your graphics card's settings. Glad to see that it was an easy fix!

Yea me too!!

Thanks again!!