Hello!
I'm running Windows Vista Ultimate (32 bit)
My issue began a couple of days ago when I ran the MS OneCare standalone scanner (I had Avast, Defender, AdAware and Spybot as my resident spyware protection, all up-to-date) and it found '1 Severe issue found - Trojan/Win32/Vundo.gen!D'
It couldn't delete it until I closed every running application I could (including Skype).
But as soon as I restarted or opened Skype it would return. I ran several Avast, Defender, AdAware and Spybot scans, they never found anything. But the OneCare scanner found it every time.
I tried running system restore to several points, and that didn't help. In fact, it would get an 'Unspecified Error' when I tried running it windows, and was only able to run system restore successfully when I booted from my Vista install CD and ran the 'Repair my computer' function.
I even did a complete PC restore to a point when I know I wasn't infected. But the Trojan was there when I ran OneCare's stand-alone scanner.
Eventually I uninstalled AdAware and Avast and installed MS OneCare with it's 90 day trial (because at least it could detect the infection).
So then I would run a scan and it would find the Trojan and quarantine/delete it. The infection would stay gone until I restarted, and then it would come back (or so my scans told me). As this was all happening I noticed that Skype kept quitting without notice.
Noting this, I tried seeing what would happen if I uninstalled Skype and then did a scan. It found the Trojan like normal and deleted it right away. I then restarted and ran the scanner again...No infection!!! Yea!
And as far as I can tell it stays gone as long as I don't have Skype. But when I did a fresh install of Skype the infection came back (and Skype started crashing again). So I uninstalled Skype and deleted the Trojan again.
And that's where I sit now. So I guess what I'm looking for is some way to totally rid myself of this infection so I can have my Skype back!
The Trojan actually hasn't given me too many issues that I know about, just Skype crashing and system restore failing. But that’s enough!
Any help would be Very appreciated. Thank you for your time and knowledge.

you have not yet tried the superantispyware program?

http://www.superantispyware.com/superantis...efreevspro.html

get the exe from http://www.superantispyware.com/downloadfi...ANTISPYWAREFREE

install it, fully update the definitions, then reboot preferably into your computers safe mode ; launch the program from the desktop icon; run a full computer scan and post back the report/log it produces

Okay,
First of all, thank you Ruby1 for your fast reply. I did as you suggested and ran the scan in safe mode after updating the scanner. Then I rebooted into Safe Mode with Networking to place this post (and to finish deleting the cookies the scanner found, as it directed me to). Here's the log it produced:

SUPERAntiSpyware Scan Log
http://www.superantispyware.com

Generated 04/21/2008 at 12:13 PM

Application Version : 4.0.1154

Core Rules Database Version : 3443
Trace Rules Database Version: 1435

Scan type : Complete Scan
Total Scan Time : 00:29:04

Memory items scanned : 220
Memory threats detected : 0
Registry items scanned : 5725
Registry threats detected : 0
File items scanned : 21574
File threats detected : 30

Adware.Tracking Cookie
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\neo_machina@ads.bleepingcomputer[1].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\neo_machina@2o7[1].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\neo_machina@revsci[1].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\neo_machina@adopt.euroclick[1].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\Low\neo_machina@media.xbox360.ign[1].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\Low\neo_machina@ads.ookla[2].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\Low\neo_machina@ads.ookla[3].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\Low\neo_machina@bp.specificclick[1].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\Low\neo_machina@adlegend[2].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\Low\neo_machina@stats1.clicktracks[1].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\Low\neo_machina@questionablecontent[1].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\Low\neo_machina@questionablecontent[2].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\Low\neo_machina@tribalfusion[2].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\Low\neo_machina@adopt.euroclick[2].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\Low\neo_machina@adopt.euroclick[1].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\Low\neo_machina@bs.serving-sys[2].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\Low\neo_machina@optimize.indieclick[2].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\Low\neo_machina@serving-sys[2].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\Low\neo_machina@ads.pointroll[1].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\Low\neo_machina@ads.pointroll[2].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\Low\neo_machina@insightexpressai[1].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\Low\neo_machina@tremor.adbureau[2].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\Low\neo_machina@interclick[2].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\Low\neo_machina@specificclick[2].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\Low\neo_machina@specificclick[1].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\Low\neo_machina@tacoda[3].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\Low\neo_machina@tacoda[1].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\Low\neo_machina@media.wii.ign[1].txt
C:\Users\Neo Machina\AppData\Roaming\Microsoft\Windows\Cookies\Low\neo_machina@stats.gamestop[1].txt
C:\Windows\System32\config\systemprofile\AppData\Roaming\Microsoft\Windows\Cookies\system@2o7[1].txt

****End Log****

I'm not sure where I go from here though...and I feel a little vulnerable sitting here in Safe Mode with Networking since it seems that none of my usual anti-virus software wants to run in it.
Anyway, as I said before; any help would be greatly appreciated.
Thanks again.

Often times that resident protection interfers with malware removal especially a program called teatimer

I suspect something is hiding from super,

http://www.besttechie.net/tools/mbam-setup.exe

run malwarebytes from regular mode

see if it catches anything

Thanks for the tip Chewy.
Yeah, I've had a love/hate relationship with TeaTimer for a while now. When this whole thing started I had TeaTimer turned off, but I turned it on back on to see if it could help me get a handle on what was happening. But, like usual, I couldn't really tell if the things it was bringing to my attention where bad or not, so I turned it back off yesterday.
Anyway, I'm currently running a scan with Malwarebytes, but - as you point out - my other programs could interfere. Should I pause/close OneCare and uninstall Spybot and then run the scan?

As long as teatimer isn't loading at bootup you are ok with spybot, I use that as one of my essential programs.

Malwarebytes and Super are 2 others I rely on for scanning. Live OneCare might be a good program but since Defender is such a bust with the security community, I kind of doubt it's effectiveness.

Thanks again Chewy,
I just finished the Malwarebyte scan, but it didn't find anything...
I'm almost wondering if I should reinstall Skype and see if I can get the infection again. Would having the Trojan to find make it easier for scanners to hunt down the root cause?
Also, as another random thought; should I do a power-cycle or reset of my Linksys? And I have a roommate on the network who has a computer without much protection on it, could he be reinfecting me via skype? It's a Mac with OSX, but he has Boot Camp with a copy of XP installed on it. Skype is installed on both OSX and XP.
Uh, that's all I can think of at the moment...
Thanks!

I read up on skype a while back and really didn't like what I saw? Look at your exceptions in your firewall and see what's running there?

That was a good call on the Firewall Chewy! I reset all settings to defaut and told it to let me know everything that wanted to connect. Since then I've done a number of scans with every tool I have and they've all come up clean. As it sits now, I think I'm good...
Thank you all so much for your attention, time and help!