This from IE-SPYAD's ReadMe text:
Uninstallation
--------------
You can uninstall IE-SPYAD in two ways:
* MANUALLY by merging .REG files (as described below);
* AUTOMATICALLY by using the IE-SPYAD Install/Uninstall
Utility (INSTALL.BAT), found in the main IE-SPYAD
installation directory.
The step-by-step directions below describe both methods, distinguishing between the two (MANUAL vs. AUTO) where appropriate.
To uninstall IE-SPYAD from Internet Explorer's Restricted sites zone:
1. Remove the IE-SPYAD List from the Restricted sites zone
MANUAL: You can uninstall IE-SPYAD manually with the uninstaller (IE-ADS-
UNINST.REG). Simply double-click on IE-ADS-UNINST.REG file. IE-
SPYAD's list of domains and servers will be removed from the
Restricted sites zone.
AUTO: You can also uninstall IE-SPYAD manually by using the IE-SPYAD
Install/Uninstall Utility (INSTALL.BAT), found in the main IE-
SPYAD installation directory.
* Note: that when you merge IE-ADS-UNINST.REG into the Registry, you'll
receive the same message as you get when you install IE-SPYAD.
Don't be confused or alarmed by this. Windows is simply informing
you that it is merging the uninstaller .REG file. That .REG file
does actually remove IE-SPYAD's entries from the Restricted sites
zone.
2. Reset Restricted sites security level (optional)
After you've uninstalled IE-SPYAD's domain/site list from the Restricted sites
zone, you may want to Reset your Restricted sites zone security setting to the
"Default Level." If you're simply going to install a new version of IE-SPYAD,
then don't reset your Restricted sites security settings -- just install the
new version of IE-SPYAD after removing the old one.
To reset the Restricted sites zone security settings: Open Internet Explorer's
"Internet Options" (off either the "View" or "Tools" menu bar option). Hit the
"Security" tab. Select the "Restricted sites." Click the "Default Level" button.
At this point, all the changes made my IE-SPYAD to Internet Explorer should be removed.